Sanofi says its COVID vaccine results show 100% efficacy against severe disease

Two doses of a new COVID vaccine that is based on a conventional approach achieved 100% efficacy against severe disease and hospitalizations, and it could be an effective booster after other COVID shots, the vaccine’s manufacturers announced Wednesday.

The vaccine, made by the Europe-based pharmaceutical companies Sanofi and GSK, is one of four candidates that received billions of dollars for development from Operation Warp Speed, the Trump administration’s program to accelerate vaccines.

The new vaccine had an efficacy of 75% against moderate-to-severe disease. It showed 58% efficacy against symptomatic disease in its Phase 3 clinical trial. Although that number is lower than was observed for the mRNA vaccines made by Pfizer-BioNTech and Moderna in their initial trials, it is “in line with expected vaccine effectiveness in today’s environment dominated by variants of concern,” Sanofi and GSK said in a statement.

The best target for COVID vaccines is a protein called a spike that covers the surface of the virus like a crown. While the mRNA vaccines contain the genetic instructions for making the protein, the Sanofi-GSK vaccine uses a slightly modified version of the protein itself to stimulate an immune response.

This is a commonly used approach for vaccines, and so may convince some people who have been hesitant to adopt the newer mRNA technology. Protein-based vaccines are also relatively inexpensive to manufacture and may not require the ultracold storage needed for the mRNA vaccines.