Is it possible to overdo it with COVID-19 vaccine boosters? What is and isn’t known

First, it was one or two COVID-19 vaccine shots. Then it was get a booster shot after eight months, until they changed it to six, then five months. Now, federal health authorities have approved yet another shot four months from your last one if you’re at least 50 or in poor health.

But is it possible to overdo it on COVID-19 vaccine boosters? Could it end up like the overuse of antibiotics that medical experts now warn is breeding superbugs resistant to them?

There’s no evidence of that yet, most experts say. But the boosting-too-much questions are fueling a growing debate among scientists as an expert panel meets April 6 to advise the Food and Drug Administration on vaccine booster doses and updates tailored to emerging variants.